| Marker | Why We Track It |
|---|---|
Total Testosterone T / TT Hormone |
The primary male sex hormone — affects muscle mass, energy, libido, mood, and body fat. "Normal" range is 300–1,000 ng/dL. The difference in how you feel at 320 vs. 850 is enormous. |
Free Testosterone Free T Hormone |
The biologically active fraction. Total T can look fine while free T is deficient — this is the number that actually determines how you feel. |
Estradiol E2 Hormone |
Critical for both men and women. In men, elevated E2 from testosterone conversion causes water retention, mood changes, and reduced libido. In women, tracks menopausal status and hormonal balance. |
LH & FSH Luteinizing & Follicle-Stimulating Hormone Hormone |
Pituitary hormones that signal the gonads to produce sex hormones. Essential for assessing the root cause of hormonal deficiencies and for monitoring Gonadorelin therapy. |
DHEA-Sulfate DHEA-S Longevity |
A precursor to sex hormones that declines steadily with age. Low DHEA-S is associated with fatigue, reduced immunity, and accelerated aging. Considered a biological age marker. |
Cortisol AM Cortisol Hormone |
The primary stress hormone. Chronically elevated cortisol breaks down muscle, increases fat storage, suppresses immune function, and disrupts sleep. Critical for performance optimization. |
IGF-1 Insulin-like Growth Factor 1 Longevity |
The primary mediator of growth hormone effects. Tracks the effectiveness of Sermorelin and GH secretagogue therapy. Also a key longevity marker — declines with age. |
Progesterone P4 Hormone |
Essential for women's hormonal balance, sleep quality, and mood. Low progesterone contributes to anxiety, insomnia, and cycle irregularities. |
Sex Hormone Binding Globulin SHBG Hormone |
Binds to sex hormones making them inactive. High SHBG reduces available testosterone even when total T looks normal. Essential for interpreting hormone panels accurately. |
Prolactin PRL Hormone |
Elevated prolactin suppresses testosterone and causes sexual dysfunction in men. Tracks pituitary health and is important when evaluating low T symptoms. |
| Marker | Why We Track It |
|---|---|
TSH Thyroid-Stimulating Hormone Thyroid |
The pituitary signal to the thyroid. The standard screening test — but an incomplete picture on its own. CORVIN uses a narrower optimal range than conventional medicine. |
Free T3 Free Triiodothyronine Thyroid |
The active thyroid hormone. Low free T3 causes fatigue, brain fog, weight gain, and depression — even when TSH is "normal." |
Free T4 Free Thyroxine Thyroid |
The storage form of thyroid hormone, converted to T3 in peripheral tissues. Tracks thyroid production and conversion efficiency. |
Reverse T3 rT3 Thyroid |
An inactive form that blocks T3 receptors. Elevated rT3 — common with chronic stress or caloric restriction — explains why some people feel hypothyroid despite normal labs. |
Thyroid Antibodies TPO-Ab / TG-Ab Thyroid |
Markers of autoimmune thyroid disease (Hashimoto's). Can be elevated years before TSH becomes abnormal — early detection changes management significantly. |
| Marker | Why We Track It |
|---|---|
Fasting Glucose FBG |
Blood sugar after fasting. Elevated fasting glucose is an early warning sign of insulin resistance — often years before an HbA1c becomes abnormal. |
HbA1c Glycated Hemoglobin |
A 3-month average of blood sugar levels. The gold standard for tracking long-term glucose control and diabetes risk. |
Fasting Insulin Insulin |
The most sensitive early marker of insulin resistance. Insulin levels rise years before glucose does — making this critical for early metabolic intervention. |
ALT / AST Liver Enzymes |
Liver health markers. Essential before prescribing any oral protocol. Also detects early non-alcoholic fatty liver disease, which is strongly linked to insulin resistance. |
GGT Gamma-Glutamyl Transferase |
A sensitive liver and bile duct marker. Also elevated with alcohol use and oxidative stress — an early longevity warning sign. |
BUN / Creatinine Kidney Function |
Kidney function markers. Required before prescribing any protocol that may affect kidney filtration. Also tracks hydration status and protein metabolism. |
eGFR Estimated Glomerular Filtration Rate |
The most accurate measure of kidney filtration capacity. Declines with age — tracking it longitudinally catches early kidney disease years before symptoms. |
Uric Acid UA |
Elevated uric acid predicts gout, kidney stones, and cardiovascular disease. Also a marker of fructose metabolism and metabolic syndrome. |
| Marker | Why We Track It |
|---|---|
LDL-Cholesterol LDL-C Cardiovascular |
Low-density lipoprotein — the primary cardiovascular risk marker. CORVIN tracks both LDL-C and LDL particle number for a complete picture. |
HDL-Cholesterol HDL-C Cardiovascular |
High-density lipoprotein — "good" cholesterol that removes LDL from arteries. Low HDL is a stronger predictor of heart disease than high LDL. |
Triglycerides TG Cardiovascular |
Blood fats that rise with insulin resistance, excess carbohydrates, and alcohol. High triglycerides with low HDL is a classic metabolic syndrome pattern. |
hsCRP High-Sensitivity C-Reactive Protein Inflammation |
The most validated marker of systemic inflammation and cardiovascular risk. Can be elevated for years before any other warning signs appear. |
Homocysteine HCY Cardiovascular |
Elevated homocysteine damages arterial walls and is an independent predictor of heart disease, stroke, and cognitive decline. Often caused by B vitamin deficiencies. |
Lipoprotein(a) Lp(a) Cardiovascular |
A genetically determined cardiovascular risk factor rarely tested in standard panels. Elevated Lp(a) is a major risk factor that requires specific management strategies. |
ApoB Apolipoprotein B Cardiovascular |
Counts the total number of atherogenic particles. ApoB is a better predictor of cardiovascular events than LDL-C — and is now considered the gold standard by leading cardiologists. |
| Marker | Why We Track It |
|---|---|
hsCRP High-Sensitivity C-Reactive Protein Inflammation |
The benchmark inflammation marker. Tracks systemic inflammatory burden and response to protocol changes over time. |
ESR Erythrocyte Sedimentation Rate Inflammation |
A non-specific inflammation marker that rises with acute illness, autoimmune conditions, and chronic infection. Useful for broad inflammatory screening. |
Ferritin Iron Storage Protein Inflammation |
Both an iron storage marker and an acute phase reactant. Very high ferritin indicates inflammation or iron overload. Very low indicates iron deficiency — even when hemoglobin is normal. |
Fibrinogen Clotting Factor Inflammation |
A clotting protein that rises with inflammation. Elevated fibrinogen increases clot risk and cardiovascular disease. A sensitive early marker of chronic inflammatory states. |
| Marker | Why We Track It |
|---|---|
Hemoglobin & Hematocrit Hgb / Hct Performance |
Oxygen-carrying capacity. Affects endurance, energy, and recovery. Critical to monitor with testosterone therapy, which can raise hematocrit to unsafe levels. |
RBC Count Red Blood Cell Count Performance |
Total red blood cells. Low RBC causes fatigue and poor exercise tolerance. Elevated RBC with testosterone therapy requires monitoring. |
WBC Count & Differential White Blood Cells Inflammation |
Total white blood cells and breakdown by type. Elevated WBC indicates infection or inflammation. The differential reveals whether the cause is bacterial, viral, or allergic. |
Platelets PLT |
Clotting cells. Low platelets increase bleeding risk. Elevated platelets increase clotting risk. Essential baseline before any injectable protocol. |
MCV Mean Corpuscular Volume |
Red blood cell size. Large MCV suggests B12 or folate deficiency. Small MCV suggests iron deficiency. Helps identify the root cause of anemia. |
| Marker | Why We Track It |
|---|---|
Vitamin D 25-OH Vitamin D Longevity |
Over 70% of adults are deficient. Vitamin D affects immune function, mood, testosterone production, muscle strength, and cancer risk. Optimal levels are 60–80 ng/mL — far above the "normal" cutoff of 30. |
Vitamin B12 Cobalamin Longevity |
Essential for nerve function, red blood cell production, and DNA synthesis. Deficiency causes fatigue, cognitive decline, and neuropathy — often misdiagnosed as depression or aging. |
Folate Vitamin B9 Longevity |
Works with B12 in homocysteine metabolism. Deficiency elevates homocysteine, increases cardiovascular and cognitive risk, and impairs DNA repair. |
Magnesium Mg Performance |
Involved in over 300 enzymatic reactions. Deficiency — extremely common — causes muscle cramps, poor sleep, anxiety, and reduced exercise performance. Standard serum magnesium misses intracellular depletion. |
Zinc Zn Performance |
Critical for testosterone production, immune function, wound healing, and taste/smell. Deficiency is common in athletes due to sweat losses and often goes undetected. |
| Marker | Why We Track It |
|---|---|
PSA Prostate-Specific Antigen Longevity |
Prostate cancer screening marker. Required baseline before testosterone therapy in men. Rising PSA on follow-up panels requires evaluation regardless of absolute value. |
Complete Metabolic Panel CMP |
Comprehensive organ function screen including electrolytes, kidney function, liver enzymes, and blood glucose — all in one panel. The essential safety check before any protocol. |
Free T3 / Reverse T3 Ratio FT3/rT3 Longevity |
The ratio of active to inactive thyroid hormone. A low ratio indicates cellular hypothyroidism — feeling exhausted despite "normal" thyroid numbers. |
Testosterone / Estradiol Ratio T/E2 Ratio Hormone |
The balance between testosterone and estrogen. Both too high and too low E2 relative to testosterone cause symptoms. This ratio guides aromatase inhibitor decisions. |